M.Sc. (Applied Physics), Ph.D. (Biophysics), Dr.Sci. (Biophysics).
Course on AACIMP 2011 — Fluorescent Proteins in Current Biology.
Country — Ukraine.
Place of employment: Leading Scientific Researcher, Head of the Research Group, Department of General Physiology of the Nervous System, Bogomoletz Institute of Physiology, Kiev, Ukraine.
Specialist in sphere of Calcium signaling; synaptic transmission; neuronal Ca2+ sensor proteins; studies of inhibitory and excitatory synaptic transmission by electrophysiological, molecular biological, imaging and pharmacological techniques.
Spheres of science researches: Mechanisms regulating intracellular cytoplasmic Ca2+ concentration ([Ca2+]i) changes in different types of excitable and non-excitable cells were the main subject of my investigations up to 2001. Mainly, optical (digital imaging and confocal microscopy) and conventional electrophysiological methods (microelectrodes, iontophoresis, patch clamp) had been employed in those studies. Our lab devised several original approaches for measurements of Ca2+ fluxes at single cell level. After establishing of my lab I have studied different mechanisms regulating synaptic transmission in the hippocampus. Mechanisms of short-term depression and non-phasic vesicular release and their relationship with calcium-dependent signaling as well as NCS (Neuronal Calcium Sensor) protein signaling in hippocampal neurons are in focus of my current research. Decoding of complex spatio-temporal patterns of [Ca2+]i changes by a Ca2+ sensor protein, hippocalcin, and involvement of Ca2+-dependent hippocalcin translocations in neuronal signal transduction is in a center of this research now.